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PANX1 channel inhibition or gene ablation downregulate EMT pathway genes in breast cancer cells. mRNA expression levels of EMT genes (N-cadherin, E-cadherin, HIF-1α, TGF-1β, Slug, Snail, Vimentin and β-catenin) in either (A) MCF-7 or (B) MDA-MB-231 cells treated with 1 mM PBN for 72 h, and MDA-PANX1– cells, quantified by qRT-PCR and normalized to GAPDH, relative to control cells. Bar graphs display results of three independent experiments. * p < 0.05, ** p < 0.01, and *** p < 0.001.
