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. 2019 Dec 1;11(12):1906. doi: 10.3390/cancers11121906

Figure 1.

Figure 1

miRNA deregulated in human and rodent human hepatocellular carcinomas (HCCs) and miRNA-based approaches in preclinical models. Top panel depicts miRNA involved in human hepatocarcinogenesis from early development to advanced stages. Downregulated miRNAs are in green; upregulated miRNAs are in red. Bottom panel depicts experimental animal models of HCC and successful miRNA treatments reducing tumor burden. miRNA mimics treatments are in green; anti-miRNA (AM) treatments are in red [3,4,5,6,7,8,9,12,15,16,17,18,19,20,21,22,23,24,25,26,27].