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. 2019 Dec 1;11(12):1906. doi: 10.3390/cancers11121906
HCC hepatocellular carcinoma
miRNA microRNA
GEM genetically engineered mouse
TG transgenic
KO knockout:
R-H model resistant hepatocyte model
TS tumor suppressor
HBV hepatitis B virus
HCV hepatitis C virus
NASH nonalcoholic steatohepatitis
NAFLD nonalcoholic fatty liver disease
CCl4 carbon tetrachloride
DEN diethylnitrosamine
EMT epithelial-to-mesenchymal transition
HFD high-fat diet
c-Myc avian myelocytomatosis virus oncogene cellular homolog
mTOR mammalian target of rapamycin
Ras Kirsten rat sarcoma viral oncogene homolog
PI3K phosphoinositide 3-kinase
AFP alpha-fetoprotein
Igf2 insulin-like growth factor 2
GPC3 beta catenin: Ctnnb1; glypican 3
PTEN phosphatase and tensin homolog
CK19 cytokeratin 19
NRF2 nuclear factor erythroid related factor 2
G6PD glucose-6-phosphate dehydrogenase
THRB thyroid hormone receptor beta
TGF-b transforming growth factor beta