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. 2019 Nov 28;11(12):1897. doi: 10.3390/cancers11121897

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FOXD1 and Gal-3 form a positive regulatory loop to promote lung cancer cell growth and motility. CL1-5 cells were transfected with scramble, si-FOXD1, or si-Gal-3 or si-FOXD1 with si-Gal-3 for 72 h. Cells lysates were collected and analyzed by immunoblotting. (A) The proliferation ability was analyzed by CCK-8. (B) Representative images of the colony-forming assay. (C) Representative images of the migration and invasion assay. CL1-0 cells were transfected with the empty vector, FOXD1, Gal-3, or both FOXD1 and Gal-3 expression vector for 48 h. (D) Proliferation ability was analyzed by CCK-8 assay. (E) Representative images of colony-forming assay. (F) Representative images of migration and invasion assay.