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. 2019 Dec 13;11(12):2014. doi: 10.3390/cancers11122014

Figure 5.

Figure 5

Targeting ARID1A sensitizes breast cancer cells to radiation. (A–C) MDA-MB-231, MDA-MB-468, and SUM159PT cells transfected with ARID1A siRNA were exposed to the indicated doses of gamma radiation and re-plated for colony formation. Around 10 days later, the colonies were stained and quantitated to evaluate surviving fractions. (D,E) MDA-MB-231 and SUM-159PT cells transfected with either an empty vector or an ARID1A overexpressing vector were irradiated with the indicated doses and re-plated for colony formation analysis. Around 10 days later, the colonies were stained and quantitated to evaluate the surviving fractions. (F) MDA-MB-231 cells previously treated with HuR siRNA were transfected with ARID1A or empty vector to test the ability of ARID1A to complement HuR-dependent radioresistance. Error bars represent SEM (standard error of the mean), * p ≤ 0.05.