Table 3.

Baseline predictive score: EPSILoN (ECOG PS, smoking, liver metastases, LDH, NLR; ε score).

Prognostic Factor	Assessment	Point
ECOG PS	1 2	0 1
Smoking (pack years)	≥40 <40	0 1
Liver metastases	No Yes	0 1
LDH (mg/dL)	<400 ≥400	0 1
NLR	<4 ≥4	0 1
Prognostic groups (points): best = 0 intermediate = 1–2 poor = 3–5

ECOG, Eastern Cooperative Oncology Group; PS, performance status; LDH, lactate dehydrogenase; NLR, neutrophil-to-lymphocyte ratio.