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. 2019 Dec 16;11(12):2026. doi: 10.3390/cancers11122026

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Transmitted light and laser scanning confocal (overlay) micrographs of blank and drug loaded double-walled PLLA (PLGA) microspheres. The distribution of DOX in Formulations B and D microspheres is indicated in green. The distribution of chi-p53 NPs in formulations C and D microspheres is indicated in red and yellow (colocalization of red and green), respectively. Scale bar = 50 μm. (b) In vitro DOX and chi-p53 release from double-walled PLLA(PLGA) microspheres. Reprinted with permission from Elsevier, Xu et al., Biomaterials, 2013 [58].