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. 2019 Dec 16;11(12):2026. doi: 10.3390/cancers11122026

Figure 11.

Figure 11

(A) Fabrication of a redox-degradable hydrogel by using horseradish peroxidase (HRP) catalysis: self-oxidation of a thiolated polymer generating hydrogen peroxide, hydrogelation (dashed arrows), HRP-mediated phenoxyradical formation promoting disulfide bond between the thiolated polymers (solid arrows). (B) Schematic of the fabrication and the recovery of cellular spheroids using redox-responsive hydrogels: encapsulation of target cells, spheroid formation by cell proliferation, recovery of the spheroids by degrading the scaffolds under reductive conditions. Reprinted with permission from Wiley, Moriyama et al., Biotechnol. J., 2016 [159].