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. 2019 Nov 25;11(12):1855. doi: 10.3390/cancers11121855

Table 2.

Clinically approved cancer nanomedicines [8,31].

Product Name Composition Indications First Approval
Doxil/Caelyx PEGylated liposomal doxorubicin Myeloma, Kaposi’s sarcoma, breast, and ovarian cancer Approved in the US (1995)
DaunoXome liposomal daunorubicin Kaposi’s sarcoma Approved in the US (1996)
Myocet liposomal doxorubicin Breast cancer Approved in Europe/Canada (2000)
Abraxane albumin-bound paclitaxel Breast, non-small-cell lung, and pancreatic cancer Approved in the US (2005)
Lipusu liposomal paclitaxel Breast and non-small-cell lung cancer Approved in China (2006)
Oncaspar L-asparaginase conjugate Acute lymphoblastic leukemia Approved in the US (2006)
DepoCyt liposomal cytarabine Lymphoma, Leukemia Approved in the US (1999)
Genexol-PM paclitaxel micellar Breast, non-small-cell lung, ovarian, and gastric cancer Approved in Korea (2007)
Mepact liposomal mifamurtide Osteogenic sarcoma Approved in Europe (2009)
NanoTherm Iron oxide nanoparticles Brain tumors Approved in Europe (2011)
Marqibo Liposomal vincristine sulfate Acute lymphoblastic leukemia Approved in the US (2012)
ONIVYDE liposomal irinotecan Advanced pancreatic cancer Approved in the US (2015)
DHP107 paclitaxel lipid nanoparticles (oral administration) Gastric cancer Approved in Korea (2016)
Vyxeos liposomal daunorubicin and cytarabine High-risk acute myeloid leukemia Approved in the US (2017)
Apealea paclitaxel micellar Ovarian, peritoneal, and fallopian tube cancer Approved in Europe (2018)
Hensify hafnium oxide nanoparticles Locally-advanced soft tissue sarcoma Approved in Europe (2019)