Table 5.

Problem definition using the PICO framework.

Problem	Heterogeneous Dataset for HSV→Difficult to Analyse and Insufficient Understanding of HSV and Associated Diseases
Intervention	Primary: HSV patient registrySecondary: interoperable with EHR
Comparison, control or comparator	Non-HSV-specific registries
Outcome	Primary: Making use of unsupervised machine learning and data science methods employing quality and searchable dataset to allow researchers to analyse HSV patient data and recruit patientsSecondary: interoperable with other data sources and EHR