Figure 1.

Clinical and histological presentation of paradoxical psoriasis induced by anti‐TNF‐α therapy in HS patients. Cutaneous lesions of patients 1–3 affected by severe HS, presenting paradoxical psoriasiform reaction after anti‐TNF‐α treatment. The patient 1 panels show paradoxical erythemato‐squamous plaques localized on the lower limbs (i and iii) and pustular lesions in the plantar region (ii). Patient 2 similarly shows erythemato‐squamous plaques on the limbs (i), pustular lesions in the palmo‐plantar region and a severe form of alopecia areata involving part of the scalp (ii–iv).The patient 3 panels reveal erythematosus patches with mild desquamation on the elbows and trunk (i–iii). H&E staining for the corresponding histopathology of patients 1 (iv) and patient 2 (v) was also performed. Scale bars, 200 μm.