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. 2019 Oct 29;6(1):55–68. doi: 10.1002/cjp2.147

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© 2019 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Innate immunity cells highly infiltrate paradoxical psoriasis skin lesions. Immunohistochemistry analysis of paradoxical skin reactions obtained from patient 1 (Pt1) and 2 (Pt2) shows an increase of BDCA2, CD15, CD117, CD68 positive cells, a reduction of CD11c cells and similar numbers of CD3 cells, when compared with psoriasis. Lesional (LS) and nonlesional (NLS) skin of the same psoriatic patient (n = 3) was analyzed. Slides were analyzed by two pathologists with experience in dermatology. Positive cells were counted in five adjacent fields at a total magnification of ×200. Graphs show the mean number of positive cells + SD per three sections. One out of three representative stainings is shown. *p < 0.01, **p < 0.05 versus classical psoriasis. Scale bars, 200 μm.