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. 2020 Jan 10;7:915. doi: 10.3389/fchem.2019.00915

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Copyright © 2020 Dittmar and Winklhofer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Domain structure of the LUBAC components. LUBAC consists of three core proteins, HOIP, HOIL-1, and SHARPIN. HOIP and HOIL-1 are RBR E3 ligases characterized by a RING - IBR (in between RING) - RING domain structure. The interaction between the UBL domains of HOIL-1 and SHARPIN with the UBA domain of HOIP releases the autoinhibition of HOIP. HOIP interacts via its PUB domain with the PIM domain of OTULIN, SPATA2, or p97/VCP.

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