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. 2020 Jan 16;11:4. doi: 10.1186/s13293-019-0280-4

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Castration (Cas) mitigated angiotensin (Ang) II-induced vascular fibrosis in Cyp1b1^+/+ mice, which was restored by 6β-hydroxytestosterone (6β-OHT). Cyp1b1^+/+ and Cyp1b1^−/− mice were castrated and infused with Ang II (700 ng/kg/day) and treated with 6β-OHT (15 μg/g b.w every third day). At the end of Ang II infusion, the aortas were removed, cut into sections, and stained with Masson’s trichrome staining for localization of collagen deposition (a, b). The percentage positive area for collagen staining was calculated. *P < 0.05 Cas + 6β-OHT vs. corresponding values from Ang II-treated animals (n = 3 for all experiments, two-way ANOVA; data are expressed as mean ± SEM)