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. 2020 Jan 16;11:4. doi: 10.1186/s13293-019-0280-4

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Flutamide reduced systolic blood pressure and vascular hypertrophy in castrated mice treated with 6β-hydroxytestosterone (6β-OHT). Castrated Cyp1b1^+/+ mice were infused with vehicle or angiotensin (Ang) II (700 ng/kg/day) and treated with 6β-OHT(15 μg/g b.w every third day) and flutamide (FLU) (8 mg/kg every day), and blood pressure was measured (a). H&E staining was performed to determine vascular hypertrophy, and the media to lumen ratio was calculated (b). The graph depicts the quantified data. *P < 0.05 Cas+6β-OHT, Cas+6β-OHT+FLU vs. corresponding values from Ang II-treated animals; ^†P < 0.05 Cas+ 6β-OHT+FLU+Ang II vs. Cas+ 6β-OHT+Ang II (n = 5 for all experiments, two-way ANOVA; data are expressed as mean ± SEM)