Table 3.
The bi-variable and multivariable Cox-regression analysis of the predictors of OIs among HIV-children on ART at Debre-Markos Referral Hospital, Northwest Ethiopia from January 1, 2005 to March 31, 2019 (N = 408)
| Variables | Events | Censored | CHR (95% CI) | AHR (95% CI) |
|---|---|---|---|---|
| Age (years) | ||||
| 0–4 years | 36 | 86 | 1 | 1 |
| 5–9 years | 63 | 112 | 1.5 (0.98, 2.3) | 1.2 (0.8, 1.9) |
| 10–14 years | 30 | 81 | 1.7 (1.03, 2.9) | 1.4 (0.8, 2.4) |
| Current status of parents | ||||
| Both alive | 59 | 160 | 1 | 1 |
| One or both dead | 70 | 119 | 1.3 (0.9, 1.8) | 1.0 (0.7, 1.5) |
| History of OIs | ||||
| No | 45 | 148 | 1 | 1 |
| Yes | 84 | 131 | 1.8 (1.3, 2.6) | 1.2 (0.8, 1.83) |
| Weight for age Z-score | ||||
| Normal weight | 55 | 152 | 1 | 1 |
| underweight | 74 | 127 | 1.4 (1.0, 2.0) | 1.1 (0.7, 1.6) |
| Height for age Z-score | ||||
| Normal | 56 | 141 | 1 | 1 |
| Stunted | 73 | 138 | 1.3 (0.9, 1.9) | 0.8 (0.5, 1.1) |
| WHO clinical stage | ||||
| Stage I and II | 41 | 176 | 1 | 1 |
| Stage III and IV | 88 | 103 | 2.9 (2.0, 4.1) | 1.8 (1.2, 2.7)a |
| CD4 counts or % | ||||
| Above the threshold | 60 | 217 | 1 | 1 |
| Below the thresheold | 69 | 62 | 3.3 (2.3, 4.6) | 1.7 (1.1, 2.6)a |
| Hgb level | ||||
| ≥ 10 g/dl | 109 | 257 | 1 | 1 |
| < 10 g/dl | 20 | 22 | 1.7 (1.1, 2.8) | 1.0 (0.6, 1.7) |
| Ever taking IPT | ||||
| Yes | 64 | 162 | 1 | 1 |
| No | 65 | 117 | 1.9 (1.3, 2.7) | 1.2 (0.8, 1.7) |
| ART adherence | ||||
| Good | 65 | 252 | 1 | 1 |
| Fair/poor | 64 | 27 | 3.7 (2.6, 5.2) | 2.6 (1.8–3.8)a |
| Past OI prophylaxis | ||||
| Yes | 51 | 204 | 1 | 1 |
| No | 78 | 75 | 2.8 (2.0, 4.0) | 1.6 (1.1, 2.4)a |
asignificant predictors