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. 2020 Jan 10;7:448. doi: 10.3389/fbioe.2019.00448

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Copyright © 2020 Sparks, Savi, Saifzadeh, Schuetz, Wagels and Hutmacher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration detailing the steps involved in a regenerative matching approach to scaffold vascularization using a corticoperiosteal flap. Firstly the flap is harvested (A,B) prior to placement into the defect and is rolled on itself (C) so the corticoperiosteum effaces the scaffold with the periosteum and blood supply internal (D). The bone is then fixated (E) and neo-osteogenesis and scaffold vascularization ensues (F,G) to generate new autologous bone. © Beth Croce, Bioperspective.com.