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. 2019 Dec 12;43(2):379–394. doi: 10.3892/or.2019.7429

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Copyright: © Yin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Identification and construction of NMIBC progression-related 13-mRNA classifier. (A) The heat map of the expression levels of 73 differentially expressed genes in the training dataset. (B) LASSO coefficient profiles of the 47 prognosis-associated mRNAs. Ten-time cross-validation was exhibited for tuning parameter selection and a vertical line was drawn at the value of the minimal λ used for establishment of 13-mRNA classifier. (C) The optimum cut-off value of the gene signature based risk scores was produced using the X-tile program in the GSE13507 training cohort. Red shows inverse association, while green indicates direct association between risk score and progression-free survival.