Table 1. The structures and experimental activities of GSK3β inhibitors. (Positions other than para substitution of R₃ are indicated explicitly in the table by ortho or meta, Where the R₃ group of the Cpd8 is in the meta position of R₂, the R₃ group of Cpd9 is in the ortho position of R₂).

No.	R1			R2		R3		IC50/(nm)		PIC50
5	H			H		H		41		7.387
8	H			H				74		7.131
9	H			H				300		6.523
10	F			H				1.3		9.114
11	CH3			H				0.46		9.337
12	CF3			H				1.1		8.959
13	CH3			CH3				1.5		8.824
14	H			F				9		8.046
15	H			CH3				6.3		8.201
16	H			H				2		8.699
*17	H			H				18		7.745
*18	H			H				4.9		8.31
No.	R1			R2		R3		IC50/(nm)		PIC50
*19	H			H				4.4		8.357
20	H			H				0.4		9.398
21	H			H				12		7.921
22	H			H				0.67		9.174
*23	H			H				20		7.699
*24	H			H				8.4		8.076
37	H			H				3.1		8.509
38	H			H				16		7.796
No.	R			X		Y		IC50/(nm)		PIC50
27	NH2			C		C		120		6.921
28	NH2			N		C		64		7.194
41	H			N		N		370		6.432
No.			R3		R5		IC50/(nm)		PIC50
25							0.22		9.658
26							0.48		9.319
44							12		7.921
45							690		6.161
46							0.99		9.004
49							74		7.131
*50							90		7.046
*51							22		7.658

* The test set molecules.