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. 2019 Nov 27;7(11):2325967119885314. doi: 10.1177/2325967119885314

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (http://www.creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — (A) Traditional analysis of graft failure rate. Risk ratio for graft failure was in favor of BPB (95% CI, 0.41-0.96; P = .03). (B) Trial sequential analysis of graft failure rate. The Z curve crossed the conventional boundary (horizontal brown lines), suggesting the superiority of BPB, but failed to cross the 2-sided significance testing boundaries, futility boundaries, and trial sequential monitoring boundaries (red curves). The sample size of included studies also did not reach the required number (vertical red line). BPB, bone–patellar tendon–bone; HT, hamstring tendon; M-H, Mantel-Haenszel; TSA-F, trial sequential analysis–.