Fig. 4.

Mean change from baseline % predicted FVC score for the 12 patients in the ITT population. Within a given visit, the best (maximum) result for the parameter of interest was used if it was from an acceptable blow as assessed by the over-reader. Baseline is the patient’s last observation prior to initiation of vismodegib. If multiple records were collected during the same visit, then the last record within that last visit was used for the analysis. FVC forced vital capacity, ITT intent to treat