Table 3.
Model predictions of peak concentration of free ciprofloxacin and time above the MIC of P. aeruginosa for four different inhaled ciprofloxacin formulations administered once daily [55]
| Drug product | Peak concentration of free cipro (µg/ml) | Time above the MIC (h) | ||||
|---|---|---|---|---|---|---|
| Trachea | Generation 5 | Generation 12 | Trachea | Generation 5 | Generation 12 | |
| CFI (270 mg) | 82.9 | 66.5 | 49.9 | 6.20 | 5.15 | 2.75 |
| CDI (189 mg) | 1323.8 | 1457.5 | 1043.4 | 5.65 | 4.65 | 2.35 |
| CIP (32.5 mg) | 52.1 | 49.9 | 40.4 | 4.90 | 4.34 | 2.84 |
| CIP (65 mg) | 57.7 | 56.3 | 48.5 | 5.69 | 5.01 | 3.32 |
| CIP (32.5 mg BID) | – | – | – | 9.80 | 8.68 | 5.68 |
Results shown for daily mucous production (DMP) of 10 ml/day and a tracheal clearance velocity (TCV) of 10 mm/min; Assumes an MIC for P. aeruginosa of 4 µg/ml