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. 2020 Jan 10;9:439. doi: 10.3389/fcimb.2019.00439

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Copyright © 2020 Ramirez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of T. cruzi telomeric recombinants and two recombinants containing retrotransposons associated sequences. Modules M1 and M2 are LTc1 retrotransposon flaking sequences: M1, RS13TC+RS1Tc (upstream); M2, Seq3Tc + SIRE associated sequences SZ (downstream); TSA, transialidase genes (or pseudogenes); L1Tc, LTc1 non-LTR retrotransposon (genes and pseudogenes); DGF1, Disperse gene family 1 genes (or pseudogenes); J, 189 bp junction; DSHX, double strand hexameric sequences; SSHX, single strand hexameric sequences. (A) Telomeric BAC6 recombinant containing T. cruzi subtelomere and telomere showing duplication of M2. (B) Telomeric cosmid C6 showing M2 duplications. (C) Recombinant pBAC62 showing multiple LTc1 retrotransposons inserted between M1 and M2. (D) Recombinant pBAC52 showing a TSA gene located downstream of 213 bp of a truncated LTc1 (T) flanked upstream by the insertion sequence GTATCTTTG and a poly A track. Probably the TSA gene was transducted by the retrotransposon. Sizes are approximated; the Flanking sequences are part of the Retrotransposon Hot Spot proteins. Adapted from Kim et al. (2005), Olivares et al. (2013).