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. 2020 Jan 10;10:3057. doi: 10.3389/fimmu.2019.03057

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Copyright © 2020 Laparidou, Schlickenrieder, Thoma, Lengyel and Schusser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Calcium mobilization signaling through CXCR4/CXCL12 interaction is inhibited when the CXCR4 receptor or the BCR receptor is inhibited. WT, CXCR4^neg, and BCR^neg DT40 cells have been labeled with FLUO-4 and stimulated with CXCL12 in order to detect calcium release by flow cytometry. Signal activity occurring from the CXCR4/CXCL12 interaction in wt cells (A) is interrupted in CXCR4^neg DT40 cells (B). A similar effect is observed in BCR^neg DT40 cells (C).