Figure 7. Gefitinib and PENAO alone and in combination were safe and well-tolerated by nude mice.

(A). Mouse body weights were measured daily and no difference between untreated and treated groups were found. Quantitative data show means ± standard error of the mean (SEM). All p values (compared to vehicle control) >0.05. (B–E) Toxicity analysis of serum biomarkers after administration of gefitinib and PENAO alone and in combination.