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. 2020 Jan 7;11(1):31–45. doi: 10.18632/oncotarget.27414

Figure 6. Inhibition of NRG1-induced tyrosine phosphorylation of HER3 and cell growth, and reactivity of anti-HER3 mAbs with human tissues and CTOS.

Figure 6

(A) Inhibition of NRG1-induced tyrosine phosphorylation of HER3 proteins by anti-HER3 mAbs in human cancer cells. (B) Effects of anti-HER3 mAbs on the cell growth of NRG1-treated BT474 cells. (C) Immunohistochemical staining of human colon carcinoma tissues with anti-HER3 mAb (Ab1). (D) Immunofluorescent staining of human colon cancer-derived CTOS with anti-HER3 mAbs (Ab1 and Ab3).