Table 2. HDT regulation of AR expression and response to antiandrogen post-HDT.
Patient | AR Alteration | ctDNA%/PCN
Pre-HDT |
HDT
Responder |
ctDNA%/PCN
Post-HDT |
Abi or Enza
Post-HDT |
PSA50
Responder |
---|---|---|---|---|---|---|
1 | Amplification | 3.9 | N | ND | Enza | Y |
2 | AR (W742C) | 1.30% | PSA50 | ND | Abi | N/A |
3 | Amplification | 1.6 | PSA30 | ND | Abi | N |
4 | Amplification | 1.5 | PSA50 | ND | Abi | N/A |
5 | AR (L702H) | 34.90% | N | 6.80% | Enza | N |
AR (V716M) | 1.20% | ND | ||||
6 | Amplification | 36.2 | N | 8.7 | Enza | N/A |
7 | Amplification | 1.4 | N | ND | Enza | Y |
AR (W742L) | ND | 1.20% | ||||
8 | AR (T878A) | 0.80% | PSA30 | ND | Enza | N/A |
9 | AR (W742C) | 0.50% | PSA30 | ND | Enza | N/A |
AR (M896V) | 5.30% | ND |