Table 1.

Compounds TKR01-TKR07 and their anti-tumour activity.

Compound	R1	R2	R3	R4	IC50 (μM)
Sorafenib	–	–	–	–	8.50
TKR01	–CH3	–H	–H	–H	101.7
TKR02	–H	–H	–CH3	–H	>100
TKR03	–H	–Cl	–H	–H	2.72
TKR04	–Cl	–H	–H	–H	>100
TKR05	–H	–H	–CF3	–H	1.25
TKR06	Naphthalene	Naphthalene	–H	–H	>100
TKR07	–H	–CH3	–H	–CH3	>100