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Reactivation kinetics of human recombinant BChE inhibited by NIMP (sarin surrogate) and NEMP (VX surrogate) using selected compounds.
| NIMP (sarin) |
NEMP (VX) |
|||||
|---|---|---|---|---|---|---|
| Compound | KD [µM] | kr [min−1] | kr2 [mM−1min−1] | KD [µM] | kr [min−1] | kr2 [mM−1min−1] |
| obidoxime (11) | 188.7 | 6.71 | 35.5 | 86.5 | 5.08 | 58.7 |
| 17 | 17.4 | 0.47 | 27.1 | 5.3 | 1.29 | 244.5 |
