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. 2020 Jan 14;8:e8370. doi: 10.7717/peerj.8370

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©2020 Shi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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The BCR repertoire diversity among SSc patients compared with the Control group. (A) Diversity between the SSc and Control (p = 0.004); (B) Shannon entropy among the mild and severe degrees of skin sclerosis patients compared with the Control group, respectively, (p = 0.02); (C) Shannon entropy among antinuclear antibody (ANA)-positive and Scl-70-positive subgroups compared with Control respectively, (p = 0.03); (D) Shannon entropy among the ILD (p = 0.02) and Non-ILD patients compared with the Control group respectively. (E) Shannon entropy among the female (p = 0.009) and male SSc patients compared with Control group. Differences were statistically analyzed for significance by the Wilcoxon rank sum test.