Table 3.

In vitro cell growth inhibition (IC₅₀) of selected compounds against multiple cancer cell lines.^a

	IC50 (μM)
Cell lines	4T1	T-47D	MCF7	A549	H460	H1299
Ribociclib	>10	6.23 ± 4.04	>10	7.46 ± 3.06	>10	5.46 ± 2.65
X8	1.46 ± 0.34	0.41 ± 0.10	1.33 ± 0.15	3.07 ± 0.11	3.22 ± 0.22	3.79 ± 0.07
X12	0.46 ± 0.07	0.16 ± 0.02	0.57 ± 0.24	1.57 ± 0.07	2.79 ± 0.32	1.31 ± 0.06
X7	0.41 ± 0.10	0.10 ± 0.02	0.23 ± 0.04	0.67 ± 0.03	0.92 ± 0.15	1.15 ± 0.10
X19	0.69 ± 0.14	0.72 ± 0.03	0.16 ± 0.06	1.46 ± 0.28	1.45 ± 0.10	0.60 ± 0.04
X20	0.26 ± 0.19	0.12 ± 0.01	0.12 ± 0.07	0.38 ± 0.02	1.50 ± 0.39	0.60 ± 0.24
X22	0.083 ± 0.34	0.11 ± 0.01	0.11 ± 0.07	0.21 ± 0.07	1.80 ± 0.34	0.57 ± 0.07

^aThe IC₅₀ values are shown in the forms. The cytotoxic effect of compounds was assayed using CCK-8 assay with 72 h incubation. Data are from three independent experiments.