4.1.A. Therapeutic indications:	1. It is easy to control their physical/chemical features over the span of assembling in accordance with the purposeful application which gives an unending assortment of releases. Thus empowers personalization of the healing and diagnostic concept [71].
	2. They permit the assembling of definitions that contain every helpful and demonstrative operator in a solitary framework [23].
	3. Their use enables payloads in excessive quantities due to large ratio between surface area and extent [72, 73].
	4. Nanoparticles are described by their dependability even under exorbitant weight and temperature [74].
	5. They are able to penetrate blood brain barrier due to their small size, further they can reach to their target sites of action effectively and avoid their detection and elimination [52].
	6. They can easily consolidate with the natural contraption of the organism that prompts terrible immunological responses [30].
	7. Enables various preparation administration by utilizing capsules that used by injection with local utility [75].
	8. Permit constant following of cure/diagnostics [34].
	9. They are ready to control medication discharge. They target neurotic sores effectively, specifically and gather inside them prompting extra proficient treatment, improvement of medication bioavailability, decline the required treatment portion which has a monetary effect [30].
	10. Provide sustained release of different antibiotics, vitamins and hormones [76].
	11. Permit cure of intracellular pathogens like brucella and leishmania further, multi antibiotic resistant pathogens such as MRSA [77, 78].
	12. Nanoparticles can be utilized for malignancy cell disposal this accomplished by method for vehicle of chemotherapeutic operators, warming the cells, particular immunological ambush of the cells [48].
	13. The utilization of nanoparticles with tumor-exact antibodies permits the end of metastatic malignant growth cells far away from the first injuries [53].
	14. Different substances like polymers, lipids and metals can be used for nanoparticles formation; they have a wide extent of dynamic parts, like chemotherapeutics and quieting medications [79], separate authorities for imaging and discovering [49], nucleic acids, proteins [50], in addition antimicrobials. A wide extent of microbial infections including tuberculosis can be treated by nanostructured antimicrobials [49]. The usage of nanocarriers is viewed as one of the valuable huge pieces of nano medicine this was confirmed by many studies that revealed the effect of them in treatment of many disease depending on traditional pharmacological bases [80 - 82].
	15. The improvement of chemotherapeutic operator which is epitomized in the nanoparticle is increasingly compelling for the treatment of constant illnesses with significantly less harmfulness and cell obstruction contrasted with standard chemotherapy specialists. For example, are very powerful inside the remedy of ovarian carcinomas while used together, but due to their excessive toxicity, lipid nanoparticle preparation of doxorubicin and paclitaxel active towards most cancer resistant cellular lines validated the efficacy of nanoparticles in tumor growth control with little toxicity [48].
4.1.B. Preventive indications:	1. Gives new plans to the headway of new antibodies with increasingly secure stable adjuvants [36].
	2. Numerous preliminaries brought about the development of remote sensors administrated to the patients under their skin in order to measure certain target proteins level [48].
4.1.C. Diagnostic indications:	1. Incorporation of nanoparticles with tumor-particular antibodies enables early prognosis of most cancers which considers better endurance rates and checking of the total casing for metastatic injuries [53].
	2. As imaging operators, which possess long duration of action and allow imaging substance to be used in a repetitive manner without side effect on liver or kidney [31].
	3. Nanorobotics can be utilized in investigatory and mending miniaturized scale medical procedures. Additionally, they can convey nano cameras for constant aid surgeries [21, 33].
	4. It provides an extremely fast screening and diagnostic property. They are able to detect large number of genes and proteins because of the presence of the usage of nano array chips with high-density [32].