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. 2019 Dec 18;9(1):1703480. doi: 10.1080/20013078.2019.1703480

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Melanin content and tyrosinase activity of B16BL6 murine melanoma cells.

Inhibition effect of melanin content on B16BL6 murine melanoma cells treated with LEVs or SEVs at 1, 5 and 10 μg/mL for 48 h. (a) melanin content inhibited by LEVs and SEVs. Inhibition effect of TYR activity on B16BL6 murine melanoma treated with LEVs or SEVs at 1, 5 and 10 μg/mL for 24 h. (b) TYR activity in melanoma cells treated with LEVs or SEVs. Melanin content and TYR activity were applied. *, ** and *** indicate difference for p < 0.05, p < 0.01 and p < 0.001 in comparison to the cells treated with cell culture media as negative control. The cells treated with arbutin were used as a positive control (n = 12).