Table 6.
Genotype frequencies of polymorphisms of EGFR gene in kidney transplant patients with and without acute rejection episodes.
| SNP | Genotype | Non-AR | AR | Models | OR (95% CI) | p Value |
|---|---|---|---|---|---|---|
| n (%) | n (%) | |||||
| rs1140475 | C/C | 257 (90.5%) | 58 (92.1%) | Codominant1 | 0.85 (0.31–2.31) | .75 |
| T/C | 26 (9.2%) | 5 (7.9%) | Codominant2 | 0.00 (0.00–NA) | 1.00 | |
| T/T | 1 (0.4%) | 0 (0%) | Dominant | 0.77 (0.28–2.10) | .60 | |
| Recessive | 0.00 (0.00–NA) | .47 | ||||
| Log-additive | 0.75 (0.28–1.97) | .54 | ||||
| rs2293347 | G/G | 127 (44.7%) | 26 (41.3%) | Codominant1 | 1.01 (0.55–1.85) | .43 |
| A/G | 127 (44.7%) | 26 (41.3%) | Codominant2 | 1.00 (0.55–1.82) | 1.00 | |
| A/A | 30 (10.6%) | 11 (17.5%) | Dominant | 1.15 (0.66–2.01) | .62 | |
| Recessive | 1.68 (0.78–3.60) | .20 | ||||
| Log-additive | 1.23 (0.82–1.83) | .32 | ||||
| rs1050171 | G/G | 223 (78.5%) | 41 (65.1%) | Codominant1 | 2.14 (1.18–3.87) | .012 |
| A/G | 56 (19.7%) | 22 (34.9%) | Codominant2 | 0.00 (0.00–NA) | .60 | |
| A/A | 5 (1.8%) | 0 (0%) | Dominant | 1.86 (1.02–3.39) | .046 | |
| Recessive | 0.00 (0.00–NA) | .15 | ||||
| Log-additive | 1.55 (0.90–2.68) | .12 | ||||
| rs6965469 | C/C | 189 (66.8%) | 44 (69.8%) | Codominant1 | 0.73 (0.39–1.39) | .34 |
| T/C | 88 (31.1%) | 15 (23.8%) | Codominant2 | 2.86 (0.78–10.58) | .12 | |
| T/T | 6 (2.1%) | 4 (6.3%) | Dominant | 0.89 (0.49–1.62) | .71 | |
| Recessive | 3.80 (0.99–14.60) | .065 | ||||
| Log-additive | 1.08 (0.65–1.81) | .77 |
EGFR: epidermal growth factor receptor; AR: acute rejection.