Table 8.
Genotype frequencies of polymorphisms of EGFR gene in kidney transplant patients with and without acute rejection episodes adjusted by patient age, sex, donor age, deceased donor, cyclosporin, tacrolimus, basiliximab and HLA mismatch.
| SNP | Genotype | Non-AR | AR | Models | OR (95% CI) | p |
|---|---|---|---|---|---|---|
| n (%) | n (%) | |||||
| rs1140475 | C/C | 174 (88.3%) | 48 (92.3%) | Dominant | 0.40 (0.12–1.33) | .11 |
| T/C | 22 (11.2%) | 4 (7.7%) | Recessive | 0.00 (0.00–NA) | .39 | |
| T/T | 1 (0.5%) | 0 (0%) | Log-additive | 0.41 (0.13–1.29) | .097 | |
| rs2293347 | G/G | 84 (42.6%) | 22 (42.3%) | Dominant | 1.08 (0.56–2.08) | .83 |
| A/G | 96 (48.7%) | 23 (44.2%) | Recessive | 2.23 (0.80–6.21) | .14 | |
| A/A | 17 (8.6%) | 7 (13.5%) | Log-additive | 1.25 (0.75–2.08) | .39 | |
| rs1050171 | G/G | 154 (78.2%) | 32 (61.5%) | Dominant | 2.74 (1.30–5.74) | .0082 |
| A/G | 41 (20.8%) | 20 (38.5%) | Recessive | 0.00 (0.00–NA) | .42 | |
| A/A | 2 (1%) | 0 (0%) | Log-additive | 2.40 (1.19–4.83) | .016 | |
| rs6965469 | C/C | 132 (67%) | 35 (67.3%) | Dominant | 1.03 (0.51–2.07) | .93 |
| T/C | 61 (31%) | 13 (25%) | Recessive | 2.93 (0.63–13.71) | .18 | |
| T/T | 4 (2%) | 4 (7.7%) | Log-additive | 1.18 (0.67–2.10) | .57 |
EGFR: epidermal growth factor receptor; AR: acute rejection; HLA: human leukocyte antigen.