Fig. 1.

Phenotypic profiles enable rapid reverse genetic screens to identify shared functions among ASD-associated genes. Plots illustrate sample mean distance of each genotype group from wild-type. Strains outside the 95% confidence interval of the wild-type distribution are labeled and colored blue. A maximum of 5 strains are labeled in each direction to prevent overplotting. (A) Length by genotype. (B) Initial response duration by genotype. (C) Habituation of response probability by genotype. Error bars represent 95% confidence interval. (D) The number of strains with normal initial responses that either impair habituation (blue) or enhance habituation (gray) across the 4 response metrics quantified.