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. 2019 Dec 30;27(1):110–127. doi: 10.1080/10717544.2019.1704940

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Classifications of states within dissolved ASDs. Dissolved API is in equilibrium with crystalline API or API in ALPS. The supersaturated state and, if the amorphous solubility is exceeded, ALPS are in a metastable state, where crystallization can occur (cryst.). Crystallization will lead to a reduction in concentration of the dissolved state down to crystalline solubility. Furthermore, there is an equilibrium between solubilized API and both dissolved states of dissolved API, i.e. the supersaturated and the not supersaturated state.