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. 2020 Jan 15;5(1):e00959-19. doi: 10.1128/mSphere.00959-19

TABLE 3.

Isogenic strain MBCs

Strain MBC (μg/ml)a
Chlorhexidine
Chlorhexidine digluconate
Benzalkonium chloride
Cetrimide
Pentamidine isethionate
Ethidium bromide
Median Max Median Max Median Max Median Max Median Max Median Max
RN4220 3.2 3.2 2 8 8 8 4 4 25 50 16 32
RN4220 ΔnorA 3.2 3.2 4 4 8 8 2 2 3.1 3.1 2 8
RN4220 ΔnorA (pCN51-norA) 3.2 3.2 4 4 8 8 8 8 50 50 16 16
RN4220 N1 3.2 3.2 4 4 8 8 4 8 50 50 32 32
RN4220 N2 3.2 3.2 8 16 16 16 8 16 100 100 32 64
RN4220 (pCN38) 3.2 3.2 4 4 4 8 2 4 25 25 16 16
RN4220 (pCN38-qacC [pSK89]) 3.2 3.2 2 4 8 8 4 4 25 25 32 32
RN4220 (pCN38-qacC [pSK41]) 3.2 3.2 4 8 32 32 8 16 25 25 256 256
RN4220 (pCN38-qacA qacR) 3.2 3.2 4 8 16 16 8 16 400 800 256 256
RN4220 ΔnorA (pCN38-qacA qacR) 3.2 3.2 8 16 16 32 4 8 400 400 128 128
RN4220 (pCN38-qacA qacR qacC [pSK41]) 3.2 6.4 8 8 16 16 16 16 200 200 256 256
RN4220 (pCN38-qacA qacR qacC [pSK89]) 3.2 3.2 8 8 32 64 16 16 200 200 128 128
RN4220 N1 (pCN38-qacA qacR) 6.4 6.4 4 8 16 16 16 16 400 400 256 256
S. aureus 2014.C02 3.2 3.2 8 8 16 16 8 16 400 800 256 512
a

Values are from 3 independent replicates. Values in italics indicate an MBC less than that of the wild type. Bold values indicate an MBC greater than that of the wild type.