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General synthetic route for the synthesis of benzenesulfonamides incorporating 1,3,5-triazine moieties. Reagents and conditions: (i) R1 (–4 F, –4MeO, –3,4diCl, and –3NO2), DMF, 0 to 5 °C, 1 h, then 30–40 °C, 8 h, (ii) R2H (dimethylamine, morpholine and piperidine), DMF, room temperature, 1 h, then 90 °C, 5 h.
