Table 2.

Anti-cholinesterase and anti-tyrosinase activity of compounds 2 and 3.

			Anticholinesterase activitya
Comp.	R1	R2	AChE assay	BChE assay	Tyrosinase activitya
2a	–4F	Cl	NA	77.41 ± 1.19	38.96 ± 0.12
2b	–4MeO	Cl	96.37 ± 1.71	91.99 ± 0.60	14.21 ± 0.40
2c	–3,4diCl	Cl	NA	87.44 ± 1.46	33.44 ± 0.82
2d	–3NO2	Cl	22.38 ± 1.09	91.40 ± 1.48	NA
3a	–4F	–N(Me)2	NA	34.67 ± 0.83	13.50 ± 0.04
3b	–4F		14.18 ± 0.41	88.76 ± 0.97	15.34 ± 0.87
3c	–4F		36.55 ± 1.17	89.21 ± 1.75	6.29 ± 0.39
3d	–4MeO	–N(Me)2	91.10 ± 1.42	96.94 ± 1.61	27.76 ± 0.22
3e	–4MeO		NA	NA	30.37 ± 0.17
3f	–4MeO		NA	95.14 ± 1.17	86.35 ± 1.39
3g	–3,4diCl	–N(Me)2	NA	10.23 ± 0.70	58.49 ± 0.86
3h	–3,4diCl		93.19 ± 2.33	98.50 ± 1.63	24.13 ± 0.52
3i	–3,4diCl		NA	88.48 ± 1.29	23.21 ± 0.97
3j	–3NO2	–N(Me)2	NA	92.14 ± 1.02	77.30 ± 1.42
	–3NO2		28.42 ± 0.76	65.44 ± 1.19	18.40 ± 0.43
3l	–3NO2		NA	94.94 ± 0.24	58.59 ± 0.89
Galantamineb		–	84.20 ± 0.74	87.86 ± 0.24	–
Kojic Acidb		–	–	–	95.26 ± 0.23

^a% inhibition values at 200 µM.

^bStandard drugs. NA: not active.