Variants by gene and patient. The genes with variants are indicated for each patient (each column represents a patient). The histograms at the top and left give the number of variants for each patient (top) and proportion of patients with variants in each gene (left). Cholangio, cholangiocarcinoma; CR, complete response; Esoph/GEJ, esophagus/gastroesophageal junction; IHC, immunohistochemistry; PancNeuroEndo, pancreatic neuroendocrine carcinoma; PD, progressive disease; PR, partial response; SD, stable disease; UE, unevaluable.