FIG 2.

(A) t-distributed stochastic neighbor embedding (t-SNE) plot showing that all samples analyzed segregated into two methylation subgroups sonic hedgehog (SHH) I (n = 10) and SHH-II (n = 15). (B) SHH-I patients were older than SHH-II patients (exact Wilcoxon-Mann-Whitney test, P = .002; n = 25). (C) Oncoprint summary describing recurrent genetic alterations and cytogenetic events observed in each methylation subgroup. iSHH, infant sonic hedgehog; MBEN, medulloblastoma with extensive nodularity; NA, not available; ND, nodular desmoplastic medulloblastoma; SNV, single nucleotide variant.