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. 2020 Jan 13;12:247–263. doi: 10.2147/CMAR.S227415

Figure 7.

Figure 7

CA6 inhibits tumor growth by modulating AKT and FoxO3a in vivo. (A) Immunohistochemical staining of harvested tumor specimens for p-Akt (Ser473), PTEN, p-FoxO3a and FoxO3a. Antigens were detected by DAB chromagen (brown). Tissues were counterstained with hematoxylin (blue) [scale bar = 50 µm]. (B) Caspase-9 activity in tumor tissue lysates [Mean ± SEM; n=6; *P<0.05, **P<0.01]. (C) Schematic illustration of the inhibitory activity of CA6 on gastric cancer growth.