Table 4. Comparison of the clinicopathological features in patients with IgG4-RD between low and high IL-6 groups.

	Low IL-6 group (n = 33)	High IL-6 group (n = 10)	p value
Age, y	63 (51–68)	72 (63–76.5)	0.014
Gender, male	25 (75.8%)	8 (80%)	0.781
Diabetes mellitus	7 (21.2%)	4 (40%)	0.233
Laboratory data
WBC, /μL	5200 (4500–6300)	6000 (4525–7650)	0.307
Hb, g/dL	13.0 (11.9–14.5)	12.1 (10.8–13.8)	0.139
Alb, g/dL	4.0 (3.5–4.4)	3.4 (2.7–3.7)	0.006
CRP, mg/dL	0.06 (0.05–0.15)	0.60 (0.27–2.64)	< 0.001
AST, U/L	23 (19–35)	46 (26–98)	0.009
ALT, U/L	22 (16–43)	37 (18–208)	0.227
ALP, U/L	292 (194–455)	490 (264–785)	0.092
T-Bil, mg/dL	0.6 (0.6–1.3)	1.6 (0.6–4.2)	0.056
IgG, mg/dL	1720 (1407–2068)	2073 (1180–3839)	0.571
IgG4, mg/dL	316 (226–684)	219 (130–619)	0.201
C3, mg/dL	85 (76–133)	68 (47–143)	0.389
C4, mg/dL	19 (12–25)	12 (2–25)	0.186
CH50, U/mL	54 (48–59)	81 (10–86)	0.332
Organ involvement
Pancreas	27 (82%)	10 (100%)	0.146
Biliary tract	19 (58%)	9 (90%)	0.060
Lacrimal gland	4 (12%)	0 (0%)	0.248
Salivary gland	15 (46%)	1 (10%)	0.042
Lymph node	17 (52%)	4 (40%)	0.523
Retroperitoneum	4 (12%)	0 (0%)	0.248
Liver	0 (0%)	4 (40%)	< 0.001
Spleen	3 (9%)	4 (40%)	0.020
Kidney	4 (12%)	4 (40%)	0.047
Aorta/artery	1 (3%)	0 (0%)	0.578
Number of organ involvement
≥ 2	29 (88%)	10 (100%)	0.248
≥ 3	19 (58%)	6 (60%)	0.892
≥ 4	9 (27%)	4 (40%)	0.443

Continuous data values are presented as the median (interquartile range).

IL-6: Interleukin-6, WBC: White blood cells, Hb: Hemoglobin, Alb: Albumin, CRP: C-reactive protein, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase, ALP: Alkaline phosphatase, T- Bil: Total bilirubin