Table 2. Antidepressant use and risk of developing MCI*.
| Model and Model Setting | HR for antidepressant exposure | 95% CI |
|---|---|---|
| Primary analyses a | ||
| Time-varying covariate model | 0.92 | 0.70, 1.20 |
| Fixed-covariate model (ever-use vs. never-use) |
0.40 | 0.28, 0.56 |
| Fixed-covariate model (baseline use vs. baseline non-use) |
0.84 | 0.61, 1.17 |
*Adjusted for age, sex, race, level of education, comorbidity history (diabetes, hypertension, hypercholesterolemia, and cardiovascular disease), smoking history, and the presence of the APOE e4 allele.
a In these primary models, antidepressant use was required to have occurred at least one visit prior to MCI diagnosis or final UDS visit. Participants were considered depressed at entry if they met two of the five criteria for depression.