Table 3. Antidepressant use and risk of developing MCI—Sensitivity analyses*.
| Model and Model Setting | HR for antidepressant exposure | 95% CI |
|---|---|---|
| 3+ Depression Criteria Required for Entry | ||
| Time-varying covariate model | 0.69 | 0.47, 1.03 |
| Fixed-covariate model (ever-use vs. never-use) |
0.23 | 0.13, 0.38 |
| Fixed-covariate model (baseline use vs. baseline non-use) |
0.67 | 0.41, 1.10 |
| GDS ≥ 6 Required for Entry | ||
| Time-varying covariate model | 1.18 | 0.75, 1.86 |
| Fixed-covariate model (ever-use vs. never-use) |
0.49 | 0.26, 0.92 |
| Fixed-covariate model (baseline use vs. baseline non-use) |
0.99 | 0.54, 1.80 |
*Adjusted for age, sex, race, level of education, comorbidity history (diabetes, hypertension, hypercholesterolemia, and cardiovascular disease), smoking history, and the presence of the APOE e4 allele.