Table 2. Medical management of Sarcoidosis according to clinical manifestation.

Renal Manifestations	Initial Treatment	Alternative Treatment	Alt. Treatment	Alt. Treatment	Comments
Hypercalcemia Hypercalciuria	Glucocorticoids Initial: 0,3-0,5mg/ kg/d Mainteance: 5-10mg/d	Hydroxychloroquine 200-400mg/day	Ketoconazol 200-800mg/day		IV hydration Limit sunlight Low intake calcium, vitD and oxalate Avoid thiazide
Granulomatous Interstitial Nephritis - GIN	Glucocorticoids Major: 1mg/kg/d Mild: 0,5mg/kg/d Mainteance: 5-10mg/d	Azathioprine 2mg/kg/day (50-200mg/d)	Mycophenolate mofetil 1g twice a day (500-3000mg/d)	Infliximab 3-5mg/kg week 0, 2, 6 for 4-8weeks	Add a steroid-sparing agent to the threatment if relapse or dificulty to taper
Glomerular Disease	Glucocorticoids Initial: 1mg/kg/d Mainteance: 5-10mg/d	After GIN alternatives	Methotrexate 10-20mg/week		Folic acid supplementation
Tubular Dysfunction	Glucocorticoids Initial: 1mg/kg/d Mainteance: 5-10mg/d	After GIN alternatives	Methotrexate 10-20mg/week		Folic acid supplementation
Nephrolitiasis	Metabolic control	Surgical threatment of lithiasis			Hypercalcemia and hypercalciuria control
Nephrocalcinosis	Metabolic control				Hypercalcemia and hypercalciuria control Higher rate of renal failure
Treatment