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. 2020 Jan 17;10:614. doi: 10.1038/s41598-019-57234-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Radiation specifically damages the brain capillaries of transgenic zebrafish. (A) A schematic representation of X-ray radiation for transgenic zebrafish at 0, 5 and 10 Gy respectively. (B) The ability of maintain stability over 15 s (top) and moving tracks of zebrafish over 1 minute (bottom) at 2-day post radiation in 0, 5 and 10 Gy group (n = 3 zebrafishes per group). (C) Live example of images (each representative of 6 zebrafishes) showing the midbrain region of the zebrafish larva, and depicting endothelial cells (green) of cerebral capillaries in 0, 5 and 10 Gy group at 4-day post radiation. The right images are magnifications of the boxed areas in left images. Scale bars, 100 µm. (D) Morphometric analyses of cerebral capillaries diameter in 0, 5 and 10 Gy group at 0 day, 2-day, 4-day post radiation respectively (n = 6 zebrafishes per group). (E) The survival analysis of zebrafishes in 0, 5 and 10 Gy group (n = 10 zebrafishes per group). (F) Live example of images (each representative of 6 zebrafishes) depicting systole and diastole of heart (red) in 0 and 10 Gy group at 2-day post radiation (left), and heart rate of zebrafishes per minute in control, 5 and 10 Gy group at 2-day post radiation (right). Statistical analysis in D and F was performed using t-test: **P < 0.05, ***P < 0.01. Data represent the mean ± s.e.m.