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. 2020 Jan 17;10:539. doi: 10.1038/s41598-019-57164-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of UWG02CTC versus UWG01CTC. (A) Immunohistochemical analysis of the expression of key proteins. The distinct phenotypes of the two CTC cell lines are highlighted in this figure; UWG02CTC expresses epithelial markers (EpCAM and E-Cadherin) as well as strong cytokeratin staining. In contrast UWG01CTC has no epithelial staining and weak/patchy cytokeratin staining. Both cell lines show high Ki67 expression supporting a high proliferation rate. No CD45 staining was seen in any of the cell lines. Scale bar 100 µm. (B) Heat-map (unsupervised hierarchical clustering) of selected gene expression profiling of CTC cultures (UWG01CTC versus UWG02CTC) with matching mouse xenografts. Count data has undergone z-score transformation to give equal mean and variance across the samples. Orange indicates a higher score, blue indicates a lower score.