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. 2019 Nov 18;476(1):147–157. doi: 10.1007/s00428-019-02683-w

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Fig. 2 — High-grade osteosarcoma. a Conventional osteoblastic osteosarcoma showing atypical cells with abundant deposition of osteoid (haematoxylin and eosin staining). Scale bar is 50 μm. b Combined binary ratio fluorescence in situ hybridization (COBRA-FISH) showing complex numerical and structural changes which is characteristic of high-grade osteosarcoma